Development of amlodipine and enalapril combined tablets based on quality by design and artificial neural network for confirming of qualitative composition

Using approaches of Quality by design, namely dispersion analysis, random balance method, regression analysis and neural networks, the composition technology tablets based on amlodipine besylate enalapril maleate have been developed. was determined effect 30 excipients 10 pharmaco-technological parameters tablets. With help desirability function, leaders were selected from 6 functional groups. It confirmed that with best parameters, using statistical methods, coincides results studies synthesized Feed-forward network. The quantities preferable at 3 levels identified method. relationship between studied factors quality described equations. Based placement equal output lines, optimal established.